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T39202 |
CZC-54252 hydrochloride
|
|
LRRK2
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|
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human... |
|
T2022 |
CZC-54252
|
CZC54252,CZC 54252 |
LRRK2
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|
CZC-54252 is a potent inhibitor of LRRK2. |
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T3478 |
Ro 67-7476
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|
GluR
|
|
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM. |
|
T4612 |
NS309
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|
EGFR
,
Potassium Channel
,
HER
|
|
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat... |
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T19659 |
Annaosanchun
|
YC6,YC-6,YC 6 |
Others
,
AMPK
|
|
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS). |
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T36851L |
Peptide5 acetate
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|
Others
|
|
Peptide5 acetate reduces animal swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 acetate significantly reduces the degree of spinal cord injury (SCI) in a rodent ex vivo model. |
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T1880 |
P7C3
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|
Others
|
|
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be... |
|
T24905 |
TT01001
|
TT-01001,TT 01001,Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate |
Mitochondrial Metabolism
|
|
TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 c... |
|
T37379 |
Protectin D1
|
Neuroprotectin D1,NPD1 |
Akt
,
PI3K
|
|
Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia/reperfusion injury and inhibits imiquimod-induced psor... |
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T21757 |
BRL 52537 hydrochloride
|
|
Opioid Receptor
|
|
BRL 52537 hydrochloride is a selective and specific KOR agonist which has been implicated in neuroprotection from ischemic neuronal injury[1]. It is used for research into potential treatments for stroke and heart attack... |
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T11518L |
GW274150
|
|
NOS
|
|
|
|
T76863 |
Elezanumab
|
AE12-1Y-QL,ABT-555 |
TGF-beta/Smad
|
|
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab pro... |
|
T28646 |
S-312-d
|
S312-d,S 312-d,S-312d,S 312d |
|
|
S-312d is a calcium channel antagonist. S-312-d can offer marked neuronal protective effects against ischemic injury. |
|
T14187 |
ALLM
|
Calpain inhibitor II |
Others
|
|
ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2]. |
|
T28247 |
ONO-1714 HCl
|
ONO-1714,ONO1714,ONO-1714 hydrochloride,ONO 1714 |
|
|
ONO-1714 is a inducible nitric oxide synthase (NOS-2) inhibitor. ONO-1714 reduces hyperoxic lung injury in mice. ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. ONO-1714 also ... |
|
T36851 |
Peptide5
|
|
|
|
Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.
O'Carroll ... |
|
T80506 |
TAT-M2NX
|
tatM2NX |
|
|
TAT-M2NX (tatM2NX) is a selective TRPM2 inhibitor that exhibits neuroprotective effects in male mice. It is utilized in research to investigate ischemic neuronal injury [1]. |
|
T78061 |
Peptide5 TFA
|
|
Gap Junction Protein
|
|
Peptide5 TFA, a connexin 43 mimetic peptide, mitigates swelling, astrogliosis, and neuronal cell death in animal models of spinal cord injury. Additionally, it suppresses the NLRP3 inflammasome, functioning as an anti-in... |
|
T60695 |
DPQ
|
|
|
|
DPQ is a potent inhibitor of PARP-1 that can be used in neuroprotection research. DPQ reduce the PARP activation induced by N-methyl-d-aspartate (NMDA), restoring ATP to near control levels as well as significantly atten... |
|
T80420 |
TAT-NEP1-40 acetate
|
|
Apoptosis
|
|
TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose deprivation (OGD) and encourages neurite outgrowth. This compound al... |
|
T70063 |
GYKI 52466 HCl
|
|
|
|
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... |
|
T21949 |
Calpain Inhibitor XII
|
|
|
|
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor targeting calpain I (μ-calpain) with a Ki value of 19 nM. It exhibits lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM)... |
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T82251 |
GW274150 dihydrochloride
|
|
NO Synthase
|
|
GW274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of 2.19 μM and Kd of 40 nM for human iNOS, a... |
|
T83727 |
Tat-NTS Peptide TFA
|
Tat-Nuclear Translocation Signal Peptide |
|
|
Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran... |
